What is LDL-C?Low-density lipoprotein cholesterol (LDL-C), often called “bad cholesterol”, can build up in the arteries and contribute to atherosclerosis and cardiovascular disease. For many, lifestyle plays a role, but genetics is often a decisive factor. Genetic causes - Familial Hypercholesterolaemia (FH): mutations in genes such as LDLR, APOB or PCSK9 reduce the body’s ability to clear LDL from the blood, leading to significantly raised levels and a higher risk of early heart disease
- Polygenic risk: in others, elevated LDL-C results from the combined effect of many small genetic variants. This polygenic profile can be as impactful as FH
Why genetic testing? - Faster diagnosis: distinguishing between FH and polygenic risk
- Family screening: early detection in relatives
- Personalised treatment: tailoring therapy intensity to your genetic profile
- Future therapies: new approaches such as PCSK9 gene editing may play a role in the future
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