CHARM cm - Lp(a) Genetics

The Importance of Lp(a) Testing

Elevated Lp(a) is not just another number – it’s a key indicator of your heart health.
This unique genetic trait increases your risk of cardiovascular disease (CVD).
Testing is recommended by several guidelines. ^1-2-3-4

Genetic Influence

Your Lp(a) levels are primarily determined by your genes and
are not significantly affected by your lifestyle or diet choices. ^5-6-7-8

The Risk Factor

Elevated Lp(a) isn’t just a number – it’s independently linked to an increased risk of heart attack, peripheral artery disease, stroke, and cardiovascular mortality. ^{9-10-11-2-12-13}A cardiovascular disease risk assessment without measuring Lp(a) is like missing a piece of the puzzle.
A simple blood test for Lp(a) can provide valuable insights into your genetic risk for heart disease. ¹⁴

References

Mach F, et al. Eur Heart J. 2020;41(1):111–188
Kronenberg F, et al. Eur Heart J. 2022;43(39):3925–3946
Grundy SM, et al. Circulation. 2019;139(25):e1082–e1143
Koschinsky ML, Bajaj A, Boffa MB, et al. A focused update to the 2019 NLA scientifi c statement on use of lipoprotein(a) in clinical practice. J Clin Lipidol. 2024;S1933-2874(24)00033-3. https://doi.org/10.1016/j.jacl.2024.03.001
Boerwinkle E, et al. J Clin Invest. 1992;90(1):52–60
Kraft HG, et al. Hum Genet. 1992;90(3):220–230
Kronenberg F. Cardiovasc Drugs Ther. 2016;30(1):87–100
Coassin S & Kronenberg F. Atherosclerosis. 2022;349:17–35
Erqou S, et al. JAMA. 2009;302(4);412–423;Kamstrup PR, et al. JAMA. 2009;301(22):2331‒2339
Clarke R, et al. N Engl J Med. 2009;361(26):2518‒2528; Langsted A, et al. J Am Coll Cardiol. 2019;74(1):54–66
Larsson SC, et al. Circulation. 2020;141(22):1826–1828
Arsenault BJ & Kamstrup PR. Atherosclerosis. 2022;49:7–16
Welsh P, et al. Eur J Prev Cardiol. 2022;28(18):1991–2000
Kronenberg F. Atherosclerosis. 2022;349:123–135